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CNN —A 62-year-old man has died months after becoming the world’s first living recipient of a genetically edited pig kidney transplant, hailed as a medical milestone. Rick Slayman received the kidney at Massachusetts General in March after he had been diagnosed with end-stage kidney disease last year. “Our family is deeply saddened about the sudden passing of our beloved Rick but take great comfort knowing he inspired so many,” a family statement said. Before Slayman’s transplant, just two transplants using pig organs had been completed – both heart transplants performed under compassionate use. EGenesis, the biotech company providing the genetically edited pig kidney, called Slayman “a true pioneer” in a statement late Saturday night.

Persons: Rick Slayman, Mr, Slayman, Slayman’s, ”, “, Rick, –, ” Slayman, Tatsuo Kawai Organizations: CNN, Massachusetts General, Massachusetts Department of Transportation, Legorreta, Procurement, Transplantation Network, Massachusetts Locations: Massachusetts, ” Massachusetts

☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

Persons: Lawrence Faucette, Ann, he’d, ” Ann, Larry Faucette, Ann Faucette Ann, Larry, didn’t, ”, Robert Montgomery, “, Shelby Lum, ” Montgomery, Xenotransplantation, Art Caplan, Caplan, Babe ”, ” Caplan, They’re, eGenesis, people’s, Dr, Mike Curtis, Sanjay Gupta, ” Curtis, hasn’t, Julie O’Hara, Jim Parsons, Jayme Locke, couldn’t, Locke, Parsons, NYU —, Montgomery —, O’Hara, ” Locke, David Bennett Sr, Mary, David Jr, Bartley Griffith, Bennett, they’ve, Muhammad M, Mohiuddin, Larry Faucette’s, David Bennett’s, ” Griffith, xenotransplantation Ann Faucette, Wilbur, White’s, Ann Faucette, NYU ethicist Caplan, they’re, NYU’s Montgomery, UAB’s Locke, Steve Wood, ’ Curtis, “ I’m, it’s, ” O’Hara, Bennett’s, Larry Faucette —, ” Bennett’s, Faucette, who’d, Griffith, would’ve, Kate, Lucy, Nadia Kounang Organizations: CNN, Food and Drug Administration, University of Maryland, FDA, National Institute of Allergy, NYU Langone Transplant Institute, NYU Langone's Transplant, NYU Grossman School, Medicine’s Department of Population Health, “ Disney, University of Alabama, Transplant Institute, Parsons Family, Birmingham, NYU, University of Maryland School of Medicine, Doctors, University of Maryland Medical Center, Uno, UAB, CNN Health, NFL Locations: Frederick , Maryland, United States, Montgomery, “, Midwest, Yucatan, Maryland

Surgeons externally attached a pig liver to a brain-dead human body and watched it successfully filter blood, a step toward eventually trying the technique in patients with liver failure. Now scientists are trying again with pigs whose organs have been genetically modified to be more humanlike. In recent years, kidneys from genetically modified pigs have been temporarily transplanted into brain-dead donors to see how well they function, and two men received heart transplants from pigs although both died within months. Political Cartoons View All 253 ImagesSome researchers also are looking to use pig livers. In a statement, the Penn team reported that the donor’s body remained stable and the pig liver showed no signs of damage.

Persons: Penn, eGenesis —, Parsia, wasn't, “, ” Vagefi Organizations: University of Pennsylvania, U.S . Food, Drug Administration, Machines, Penn, UT Southwestern Medical Center, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: U.S

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